Tag Archives: Triple Negative Breast Cancer

Potential New Drug for Triple-Negative Breast Cancer

Dana-Farber scientists this year identified a promising new drug for a form of breast cancer and discovered one way the disease can outmaneuver the drug. The findings, reported in the journal Nature, may lead to a more farsighted treatment strategy for breast cancers classified as “triple-negative” – one that uses drug combinations to both arrest the disease and prevent it from resisting front-line therapies. The dual approach could significantly extend patient survival times, the authors say.
Kornelia Polyak, M.D., Ph.D.
 
“We found that a class of agents known as BET bromodomain inhibitors significantly impeded the growth of triple-negative breast cancer cells in …

 

Susan F. Smith Center for Women’s Cancers Breast Cancer Program

Eric Winer, MD
Research into improving the effectiveness of therapies for breast cancer continues at a rapid pace in the Breast Cancer Program. More than 40 clinical trials for breast cancer are taking place at Dana-Farber or our affiliated institutions. Researchers are working to develop new agents for drug-resistant cancers, identify additional subtypes of tumors that respond to targeted treatments, uncover the biochemical signs of a tumor’s aggressiveness and vulnerability to therapy, and devise new approaches to cancer prevention and      supportive care.
Susan F. Smith Center for Women’s Cancers (SSC) investigators are tackling cancer on multiple fronts, including triple-negative breast cancers (so …

 

Dana-Farber scientists identify overactive genes in aggressive breast cancers

Potential new drug target for hard-to-treat ‘triple-negative’ disease

Kornelia Polyak, MD, PhD

Scientists at Dana-Farber Cancer Institute have identified an overactive network of growth-spurring genes that drive stem-like breast cancer cells enriched in triple-negative breast tumors, a typically aggressive cancer that is highly resistant to current therapies.
Kornelia Polyak, MD, PhD, a breast cancer geneticist at Dana-Farber, and colleagues found that a large proportion of cells within these tumors showed elevated activity in a network of genes called the Jak2/Stat3 pathway.
Experiments have demonstrated that a drug specifically aimed to block this pathway halted the growth …

 

Scientists Identify Overactive Genes in Aggressive Breast Cancers

Source: Dana-Farber Cancer Institute
Potential new drug target for hard-to-treat ‘triple-negative’ disease
Newswise — BOSTON—Scientists at Dana-Farber Cancer Institute have identified an overactive network of growth-spurring genes that drive stem-like breast cancer cells enriched in triple-negative breast tumors, a typically aggressive cancer that is highly resistant to current therapies.
Kornelia Polyak, MD, PhD, a breast cancer geneticist at Dana-Farber, and colleagues found that a large proportion of cells within these tumors showed elevated activity in a network of genes called the Jak2/Stat3 pathway. Experiments have demonstrated that a drug specifically aimed to block …

 

Life without Colleen, Pete O’Farrell’s Journey

I have been living my new life for just over a year. It is not one that I would have ever chosen, but sometimes you don’t get what you want. My wife Colleen passed away on January 14, 2010 from Triple Negative Breast Cancer. We had an amazing ten years together that I treasure more and more as time passes, but now what? I made a promise to her that our kids would not forget her. One of her greatest fears was that since our children were so young, only four and six at the …

 

Colleen Horan O’Farrell The Child She Was And The Woman She Would Become

Colleen was full of energy and spirit from the moment she was born.  I often said she never learned to walk….crawling was much too slow, so she went directly to running.  She was always climbing…..out of the crib, out of the playpen, then graduating to hills and trees.  Our neighbor dubbed her, “Monkey.” Oh so many times I heard, “Don’t break her spirit,” when I was merely trying to keep her from breaking her neck.
She took swimming lessons early because she loved the water and the beach, and was too impatient to bother with a life jacket.  A …

 

Guardian of Colleen’s Memory, Pete O’Farrell shares his Story

When I was asked to write about my wife Colleen and her battle with Breast Cancer I didn’t really know how to approach the subject.  Colleen was the love of my life so I see this as a monumental task, also I see myself as a guardian of her memory.  I do this out of my love for her, and to make sure that our two children know of the incredible woman who was and is their mother.  How can one convey such an amazing woman in words?  Anyone who knew Colleen knows that she can not be summed up …

 

Guardian of Colleen's Memory, Pete O'Farrell shares his Story

When I was asked to write about my wife Colleen and her battle with Breast Cancer I didn’t really know how to approach the subject.  Colleen was the love of my life so I see this as a monumental task, also I see myself as a guardian of her memory.  I do this out of my love for her, and to make sure that our two children know of the incredible woman who was and is their mother.  How can one convey such an amazing woman in words?  Anyone who knew Colleen knows that she can not be summed up …

 

Boston Bake for Breast Cancer 2011 is Dedicated to the Memory of Colleen O'Farrell

We are proud to announce that Boston Bakes for Breast Cancer 2011 is dedicated to the Memory of Colleen O’Farrell, a loving wife and mother of two young children who lost her battle with breast cancer in January of 2010.
Boston Bakes for Breast Cancer got to know and see Colleen every year when we would bring desserts from our participants to the Fox 25 Dedham studio for our Boston Bakes segments on the Fox 25 Morning News Show. Colleen was a part of the team having joined the morning show as a studio technician in 2003, began as a writer …

 

Boston Bake for Breast Cancer 2011 is Dedicated to the Memory of Colleen O’Farrell

We are proud to announce that Boston Bakes for Breast Cancer 2011 is dedicated to the Memory of Colleen O’Farrell, a loving wife and mother of two young children who lost her battle with breast cancer in January of 2010.
Boston Bakes for Breast Cancer got to know and see Colleen every year when we would bring desserts from our participants to the Fox 25 Dedham studio for our Boston Bakes segments on the Fox 25 Morning News Show. Colleen was a part of the team having joined the morning show as a studio technician in 2003, began as a writer …