Tag Archives: Clinical Trials

Dana-Farber Patient Stays Positive Through Metastatic Breast Cancer

At 29 years old, Adriana, 38, of Massachusetts, was diagnosed with metastatic (stage four) breast cancer after noticing a lump in her breast and feeling some “strange symptoms.” Only three months after a move across the country, Adriana was told her best bet would be to move back home for her treatment. “I talked to some doctors down in Florida, and they said to me, ‘You’re not going to get good care down here, if you’re from Massachusetts, go back to Dana-Farber’” said Adriana. “Within a few months, I had moved to Florida, packed up my bags and went back …


Metastatic Breast Cancer Survivor Thriving on Clinical Trial

A clinical trial at Dana-Farber has kept Sharon DeCosta’s stage IV metastatic breast cancer stabilized for three years, allowing her a full life of traveling and doting on her three young grandchildren, with a fourth due in December.
It may seem odd that DeCosta celebrates the anniversary of her diagnosis each year with a toast, until you realize the significance of the date.
“I found out I had cancer on April 27, 2015—my twenty-fifth wedding anniversary,” says DeCosta. “When the doctor told me I thought, ‘Wait a minute, I’m supposed to be on a beach somewhere sipping on a margarita, not hearing …


The Susan F. Smith Center for Women’s Cancers at Dana-Farber: Creating Powerful Possibilities

A clinician and a scientist meet on the bridge that connects the research and patient-care buildings to discuss how a laboratory finding might benefit patients. A young woman, newly diagnosed with breast cancer, finds solace in a support program of her peers. A young investigator identifies molecular subtypes of ovarian cancer.
These are just a few of the powerful possibilities the Susan F. Smith Center for Women’s Cancers at Dana-Farber creates by bridging compassionate care and world-class basic and clinical research. This edition of Turning Point shares stories like these, and others. Innovators in Women’s Cancers Innovation occurs when experts in …


Exploring the Molecular Workings of Breast and Gynecologic Cancers

J. Dirk Iglehart, MD
By exploring the molecular workings of breast cancer and gynecologic cancers, researchers and clinicians at Dana-Farber Cancer Institute’s Susan F. Smith Center for Women’s Cancers (SSC) are gaining new insights into the many subtypes of these diseases. Under the leadership of J. Dirk Iglehart, MD, they are also studying how genetic similarities among different cancers can be exploited to develop more effective therapies.
The center’s many clinical trials – about 65 are currently open and a comprehensive list is available at www.dana-farber.org/ clinicaltrials – provide patients with the latest treatments and therapeutic developments. Many trials evaluate treatments prior …


Scientists Identify Overactive Genes in Aggressive Breast Cancers

Source: Dana-Farber Cancer Institute
Potential new drug target for hard-to-treat ‘triple-negative’ disease
Newswise — BOSTON—Scientists at Dana-Farber Cancer Institute have identified an overactive network of growth-spurring genes that drive stem-like breast cancer cells enriched in triple-negative breast tumors, a typically aggressive cancer that is highly resistant to current therapies.
Kornelia Polyak, MD, PhD, a breast cancer geneticist at Dana-Farber, and colleagues found that a large proportion of cells within these tumors showed elevated activity in a network of genes called the Jak2/Stat3 pathway. Experiments have demonstrated that a drug specifically aimed to block …